Data and terms
Real patient data must never be entered into this demo.
GIAB and 1000 Genomes samples are not linked to Synthea patients. The research plane and the clinical plane stay separate.
The clinical records are Synthea output. Synthea's default geography is Massachusetts in the United States. They are not European patients.
This host has no bring-your-own-data sandbox. Run the software locally. A sandbox is not deployed here.
Verified on the laptop, not yet on a public host.
HELIOS signing public key
Signed HELIOS reports on this demo are verified against an Ed25519 public key. SHA-256 of the public key file: fe3a4604ec534b28672148b3aba58ca85863626fa4114a5af954924fc620dda1. First used (UTC date): 2026-10-11. Auditors can download /helios-report.json and check the signature against that key (trust store or helios validate).
fe3a4604ec534b28672148b3aba58ca85863626fa4114a5af954924fc620dda1
If the key is rotated, this page will show the new fingerprint and date, and the previous public key will be archived as retired (see docs/RUNBOOK.md). A demo reset does not rotate the key.
| Source | Kind | Bytes | Terms | Citation |
|---|---|---|---|---|
| HG001_GRCh38_1_22_v4.2.1_benchmark.vcf.gz | public reference, GIAB NIST benchmark | 125932193 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG001_GRCh38_1_22_v4.2.1_benchmark.bed | public reference, GIAB NIST benchmark | 15479939 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG002_GRCh38_1_22_v4.2.1_benchmark.vcf.gz | public reference, GIAB NIST benchmark | 156252944 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG002_GRCh38_1_22_v4.2.1_benchmark_noinconsistent.bed | public reference, GIAB NIST benchmark | 11494021 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG003_GRCh38_1_22_v4.2.1_benchmark.vcf.gz | public reference, GIAB NIST benchmark | 147212428 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG003_GRCh38_1_22_v4.2.1_benchmark_noinconsistent.bed | public reference, GIAB NIST benchmark | 13219856 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG004_GRCh38_1_22_v4.2.1_benchmark.vcf.gz | public reference, GIAB NIST benchmark | 148948118 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG004_GRCh38_1_22_v4.2.1_benchmark_noinconsistent.bed | public reference, GIAB NIST benchmark | 13081043 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG005_GRCh38_1_22_v4.2.1_benchmark.vcf.gz | public reference, GIAB NIST benchmark | 139334496 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG005_GRCh38_1_22_v4.2.1_benchmark.bed | public reference, GIAB NIST benchmark | 18615340 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG006_GRCh38_1_22_v4.2.1_benchmark.vcf.gz | public reference, GIAB NIST benchmark | 117161667 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG006_GRCh38_1_22_v4.2.1_benchmark.bed | public reference, GIAB NIST benchmark | 15762527 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG007_GRCh38_1_22_v4.2.1_benchmark.vcf.gz | public reference, GIAB NIST benchmark | 118171165 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| HG007_GRCh38_1_22_v4.2.1_benchmark.bed | public reference, GIAB NIST benchmark | 16208979 | NIST GIAB FAQ: data may be used with no embargo. Cite the dataset README and https://www.nature.com/articles/sdata201625. Benchmarks also cite https://www.nature.com/articles/s41587-019-0054-x. NIST works of employees are not subject to US copyright under 17 USC 105. See docs/SEED.md. | Zook et al., Scientific Data 2016, https://doi.org/10.1038/sdata.2016.25; Krusche et al., Nature Biotechnology 2019, https://doi.org/10.1038/s41587-019-0054-x |
| chr21.fna.gz | public reference genome, chromosome 21 only | 11119238 | NCBI genomes FTP README for GCA_000001405.15 contains no licence paragraph. Assembly report header: Assembly name: GRCh38; Description: Genome Reference Consortium Human Build 38; Organism name: Homo sapiens (human); Taxid: 9606; BioProject: PRJNA168; Submitter: Genome Reference Consortium; Date: 2013-12-17; Synonyms: hg38. This file is chromosome 21 only, not the full assembly. | NCBI assembly GCA_000001405.15 (GRCh38), chromosome 21 only |
| ALL.chr21.phase3.first5.vcf.gz | public reference, 1000 Genomes subset | 17288199 | IGSR disclaimer (https://www.internationalgenome.org/IGSR_disclaimer): Data from the 1000 Genomes Project is now available without embargo, following the final publication from the project. Use of the data should be cited in the usual way. The phase3 callset README (README_phase3_callset_20150220) describes the release and does not itself state a licence. The citation page says the Nature paper is CC-BY-NC-SA 3.0; that sentence is about the paper, not a licence this demo assigns to the VCF. | The 1000 Genomes Project Consortium, A global reference for human genetic variation, Nature 526, 68-74 (2015), doi:10.1038/nature15393. File ALL.chr21.phase3_shapeit2_mvncall_integrated_v5b.20130502.genotypes.vcf.gz. |
| beacon-chr21-first500-snv.vcf.gz | public reference, beacon-sized extract | 9999 | IGSR disclaimer (https://www.internationalgenome.org/IGSR_disclaimer): Data from the 1000 Genomes Project is now available without embargo, following the final publication from the project. Use of the data should be cited in the usual way. The phase3 callset README (README_phase3_callset_20150220) describes the release and does not itself state a licence. The citation page says the Nature paper is CC-BY-NC-SA 3.0; that sentence is about the paper, not a licence this demo assigns to the VCF. | The 1000 Genomes Project Consortium, A global reference for human genetic variation, Nature 526, 68-74 (2015), doi:10.1038/nature15393. File ALL.chr21.phase3_shapeit2_mvncall_integrated_v5b.20130502.genotypes.vcf.gz. |
| synthetic-cohort | synthetic | None | Invented cohort. Not people. | s4-showcase seed/synthetic/cohort.json |
| synthetic-variants | synthetic | None | Invented VCF sites. Not GIAB. | s4-showcase seed/synthetic/variants.vcf |
| synthetic-regions | synthetic | None | Invented BED intervals. | s4-showcase seed/synthetic/regions.bed |
| Synthea patients | synthetic clinical | None | Generated locally. Synthea default geography is the United States. Not linked to GIAB or 1000 Genomes. | Synthea jar sha256:018ad7f04f7aacb995804d7d4781c76d5fc714f7f23257ba50daa9eefae224ac, release id 372490833, seed 42, population 30. |